Chem. Commun., 2003, (Advance Article) DOI: 10.1039/b303508e | ![]() Communication |
Glycoluril ribbons tethered by complementary hydrogen bonds |
Darren W. Johnson,
Fraser Hof,
Liam C. Palmer,
Tomás Martín,
Ulrike Obst and
Julius Rebek, Jr.*
The Skaggs Institute for Chemical Biology and the Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Four complementary hydrogen bonds between sulfamides and ureas link adjacent hydrogen-bonded ribbons to form sheets in the solid-state; this interaction is investigated in solution using model urea and sulfamide compounds.
We recently reported a series of achiral glycoluril monomers that form chiral hydrogen-bonded ribbons in the solid-state.1 The ribbons propagate by hydrogen-bonding between adjacent glycoluril monomers,2–4 wherein the urea protons donate intermolecular hydrogen bonds to adjacent carbonyl oxygen atoms.
Isaacs and coworkers recently reported similar hydrogen-bonded chiral ribbons in a related syn-protected glycoluril monomer,5 and Grossman and coworkers have reported analogous monomers that form rosettes or ribbons in the solid-state depending on the crystallization conditions.6 Here we report a new glycoluril monomer (1) affixed with an additional sulfamide hydrogen-bonding motif (Fig. 1). The new functionality serves to bridge adjacent ribbons via specific sulfamide–glycoluril hydrogen bonds. These complementary hydrogen-bonding interactions between ureas and sulfamides7 provide an unanticipated driving force for forming higher order two-dimensional sheets over one-dimensional ribbons.8,9
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Fig. 1 Crystal structure of glycoluril monomer 1 used in this study. |
Urea and sulfamide functionalities discriminate against homodimerization in solution by forming a strong hydrogen-bonded heterodimer (2·3, Fig. 3); this recognition motif has been used to assemble discrete capsules in solution and in the solid-state.7,10,11 Monomer 1 was prepared to investigate the propensity for the urea and sulfamide functionalities to interact in the solid-state and form discrete tetrameric capsules; however, capsule formation was never observed. Rather, an unusual two-dimensional network of hydrogen bonds that maintains the programmed head-to-tail specificity between glycoluril and sulfamide is observed.
Compound 1 is readily prepared by alkylation of 1,6-bis(p-methoxybenzyl)-7,8-di-p-tolylglycoluril with an o-dibromomethyl-arylsulfamide followed by deprotection (see experimental section). Slow evaporation of a 1,2-dichloroethane–methanol solution provides crystals suitable for X-ray diffraction measurements (Fig. 1). Monomer 1 cocrystallizes with 1,2-dichloroethane in monoclinic space group P21/c with four molecules of each in the unit cell.
The fused seven-membered ring of 1 precludes the chiral twisting observed in earlier glycoluril structures.1,2,5 Similar to other syn-protected glycolurils, the glycolurils form an extended one-dimensional ribbon in the solid-state coincident with the 21 crystallographic screw axis (highlighted in orange in Fig. 2). Interestingly, one sulfonyl oxygen and both sulfamide protons of 1 (shown in green in Fig. 2) form intermolecular hydrogen bonds with glycoluril amide protons and carbonyl oxygens: the sulfamide oxygen bisects the curved surface of an adjacent glycoluril monomer and accepts two hydrogen bonds from the syn-ureido glycoluril protons. The sulfamide protons also donate two hydrogen bonds to two different glycoluril carbonyl oxygens along the ribbon. This specific hydrogen-bonding between glycolurils and sulfamides bridges adjacent ribbons to create two-dimensional sheets without disrupting the one-dimensional ribbon motif.
We have previously reported qualitative results on the recognition between ureas and sulfamides in solution.7 To gain quantitative insight into this interaction, model compounds were prepared to determine the association constant of these urea–sulfamide heterodimers (Fig. 3). Each monomer self-associates (2·2, 3·3) with a modest homodimerization affinity in CD2Cl2 of Ka = 1.1 and 0.7 M–1, respectively. An equimolar mixture of urea 2 and sulfamide 3 exhibits very different behavior. Fitting12 the dilution curve to a 1 : 1 isotherm gives a binding constant of 50 M–1 for the heterodimer. A Job plot confirms that the binding takes place in a 1 : 1 stoichiometry.13
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Fig. 3 Specific hydrogen-bonding between simple donor–acceptor molecules. Urea 2 homodimerizes (2·2) in CD2Cl2 with a Ka of 1.1 M–1. Sulfamide 3 homodimerizes (3·3) in CD2Cl2 with a Ka of 0.7 M–1. A mixture of 2 and 3 selectively forms heterodimers (2·3) with a Ka of 50 M–1. R = C12H25, R![]() |
This selective hydrogen-bonding between 2 and 3 arises from a complementary electrostatic attraction. The most acidic (and therefore the most electropositive) hydrogen bond donor in the system belongs to the sulfamide proton (pKa 6.5).14 The most electronegative hydrogen bond acceptor belongs to the carbonyl of the urea. This results in a complementary donor–acceptor hydrogen-bonding pair with a significant preference for heterodimerization over homodimerization—almost two orders of magnitude higher affinity.
The use of specific, complementary interactions (such as hydrogen-bonding) between different functional groups is an important tenet of crystal engineering.15,16 We have shown that a solid-state structure exhibits an additional dimension of ordering that uses a complementary hydrogen-bonding interaction observed in solution. Due to the ready availability of sulfamides and ureas, their complementary hydrogen-bonding preferences suggest application in the formation of engineered solids.
The authors thank Professor Ian A. Wilson and Dr Xiaoping Dai for use of the X-ray diffractometer. The following agencies are gratefully acknowledged for fellowship support: the NIH (D. W. J.), the Skaggs Foundation (F. H.), NASA (L. C. P.), MEC (Spain, T. M.), and the DFG (Germany, U. O.). Additional funding for this research was provided by the Skaggs Foundation and the NIH.
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